AROMASIN 20

Exemestane is indicated for the adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of tamoxifen and are switched to it for completion of a total of five consecutive years of adjuvant hormonal therapy. US FDA approval was in October 1999.

Exemestane is also indicated for the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.

For premenopausal women with hormone-receptor–positive breast cancer, adjuvant treatment with ovarian suppression plus the aromatase inhibitor exemestane, as compared with ovarian suppression plus tamoxifen, provides a new treatment option that reduces the risk of recurrence. The TEXT and SOFT trials demonstrated improved disease free survival in patients treated with exemestane and ovarian suppression compared to the tamoxifen and ovarian suppression group. Premenopausal women who receive ovarian suppression may now benefit from an aromatase inhibitor, a class of drugs that until now has been recommended only for postmenopausal women.

Contraindications
The drug is contraindicated in premenopausal women, which of course includes pregnant and lactating women.

Side effects
The most common side effects (more than 10% of patients) are hot flashes and sweating, which are typical of estrogen deficiency as caused by exemestane, and also insomnia, headache, and joint pain. Nausea and fatigue are mainly observed in patients with advanced breast cancer.

An occasional decrease in lymphocytes has been observed in approximately 20% of patients receiving Aromasin, particularly in patients with pre-existing lymphopenia.

Exemestane has androgenic properties similarly to formestane and can produce androgenic side effects such as acne and weight gain, although these are generally associated with supratherapeutic dosages of the drug.

Aromasin Cycle: In the bodybuilding community the recommended dosage to avoid estrogen buildup is 12.5 mg to 25 mg a day. Aromasin is one of the most potent anti-estrogen drugs on the market with studies reporting estrogen levels being lowered as much as 85% in a group of women. 12.5 mg every other day prove effective for some individuals. Finding out what dosage is appropriate per each individual is important, especially with such a potent anti-estrogen, as too little estrogen in one’s system can actually reduce muscle gains and diminish the sex drive.

Warning: Keep out of reach of children. For adults only